Microbe
Akkermansia muciniphila
The Genome of Akkermansia muciniphila, a Dedicated Intestinal Mucin Degrader, and Its Use in Exploring Intestinal Metagenomes
A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
Genome sequencing of 39 Akkermansia muciniphila isolates reveals its population structure, genomic and functional diverisity, and global distribution in mammalian gut microbiotas
Bacillus licheniformis
Preferential attachment and colonization of the keratinolytic bacterium Bacillus licheniformis on black- and white-striped feathers
Bacteroides thetaiotaomicron
Intragenic DNA inversions expand bacterial coding capacity
Thiamine (VB1) biosynthesis protein ThiC in Bacteroides thetaiotaomicron contains an inverton that introduces a premature stop codon when inverted. This species has the capacity to biosynthesize thiamine at a large energetic cost. This work showed that at human intestinal thiamine concentrations (0.02–2 μM), strains with inverted inverton were more fit than prototrophic strains. However, thiamine availability does not promote rapid thiC inversion flipping, suggesting stochastic dynamics. It fits a bet-hedging model.
Clostridium symbiosum
Gut pathogen Clostridium symbiosum rewires macrophage succinylation to drive enteric neuron loss in inflammatory bowel disease
Cordycipitaceae
Defensive fungal symbiosis on insect hindlegs
Fusobacterium nucleatum
A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche
Salmonella enterica
Pan-genome Analysis of Ancient and Modern Salmonella enterica Demonstrates Genomic Stability of the Invasive Para C Lineage for Millennia
Veillonella atypica
Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism
Scheiman et al. 2019 provides an example of a host-microbiome metabolic feedback loop linking exercise-induced lactate to microbial propionate production and endurance performance. It illustrates how exercise shapes the gut microbiome.
Host
Others
Into the Thin Air by Jon Krakauer